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- W2385164974 abstract "Objective To explore the toxic mechanism of carbon disulfide (CS2) in term of adjusting and balancing function of the hypothalamic-pituitary- ovary axis. Methods SD rats were given CS2 with dose of 400 mg/ kg and 100 mg/ kg for 14 days and 28 days respectively and the changes of serum follicle- stimulating- hormone (FSH ), luteinizing hormone (LH), Progesterone (P) and estrogen (E2) in rat estrus were measured. In addition, rat in estrus was given gonadotropic-release hormone (GnRH) to stimulate pituitary secretion. Results As exposure dose increasing and exposure time prolonging, it was showed that the time of estrus cycle in rats was delayed to certain extent and even rats' estrus seemed to be disappeared. The ratio of ovary to body weight in CS2 group was increased significantly with comparison to that of control group (P 0. 05). LH was significantly increased in those two treated groups than that in control group (P 0. 05). Except that serum levle of P of high dose group was significantly increased 60 minutes after injection of GnRH than that of low dose group and control group (P 0. 05), there was no difference of serum hormone level among each group (P 0. 05). Conclusion It concluded that CS2 might have adverse effect on female-gonad and indicated that the reservating function of pituitary in rats was not reduced in GnRH-stimulating-test, however, the possibility of GnRH super-response in rat was unable to be excluded." @default.
- W2385164974 created "2016-06-24" @default.
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- W2385164974 date "2001-01-01" @default.
- W2385164974 modified "2023-09-27" @default.
- W2385164974 title "Study on mechanism of female gonad toxicity induced by carbon disulfide in rats" @default.
- W2385164974 hasPublicationYear "2001" @default.
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