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- W2385184840 abstract "A pH-responsive carrier was prepared by electrostatic interaction between positively charged mesoporous silica nanoparticles and negatively charged poly(acrylic acid).The physical and chemical properties of the as-synthesized mesoporous silica nanoparticles were characterized by transmission electron microscopy(TEM),X-ray diffraction assay(XRD),Fourier transform infrared spectroscopy(FTIR),Brunauer-Emmett-Teller(BET) and Barrett-Joyner-Halenda(BJH) analyses.Loading efficiency and controlled release properties of the carrier were investigated with [Ru(bipy) 3]Cl 2 dyes as guest molecules.It was demonstrated that the mesoporous silica nanoparticles carrier was very sensitive to pH and exhibited good property of pH-responsive release.At neutral pH,positively charged nanoparticles interacted with negatively charged poly(acrylic acid) by electrostatic adsorption,resulting in the closing of the mesopores.The dyes could hardly be released from the nanoparticles.When the pH value was decreased,the percentage release of dye molecules increased.The dye was released sharply when the pH value was lower than 5.Cumulative release of the dye reached to 98% at pH=1.0,280 min.These results demonstrated that the release of the guest molecules could be controlled by pH adjustment.This new type of pH-responsive controlled release system based on mesoporous silica nanoparticles has the advantages of simply synthesis,low cost,and large load capacity,which made it have potential application in drug controlled release." @default.
- W2385184840 created "2016-06-24" @default.
- W2385184840 creator A5055719410 @default.
- W2385184840 date "2012-01-01" @default.
- W2385184840 modified "2023-09-26" @default.
- W2385184840 title "Preparation of a pH-Responsive Carrier Based on Mesoporous Silica Nanoparticles and Its Application for Controlled Release" @default.
- W2385184840 hasPublicationYear "2012" @default.
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