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- W2385193724 abstract "Objective To investigate the effect of glucose and cholesterol on expression of angiopoientin-like protein 3 (ANGPTL3) in human liver cells (L02),and to explore the relation of ANGPTL3 with the development of diabetes mellitus and hypercholesteremia.Methods Human liver cells (L02) werw used as cellular settings in this study,as divided into glucose groups and cholesterol groups. The two groups of L02 cells were incubated in the medium containing 5.6,7.0,11.1,28.0,33.0 mmol/L of glucose,or 10,25,50,100 μmol/L of cholesterol,respectively. The relative level of ANGPTL3 mRNA expression was detected by reverse transcription-polymerase chain reaction (RT-PCR).The relative level of ANGPTL3 protein was measured by western blot.Results Glucose at the concentration of 11.1,28.0 and 33.3 mmol/L significantly stimulateed ANGPTL3 mRNA expression in L02 cells,with a linear dose-dependent manner (P0.05). Cholesterol at each dose of 10,25,50,100 μmol/L upregulated ANGPTL3 expression at both gene and protein level,with the significance of P0.01.Conclusions Certain concentration of glucose and environmental cholesterol upregulate the expression of ANGPTL3 gene and protein level. ANGPTL3 might play an important role in diabetes mellitus and hypercholesteremia." @default.
- W2385193724 created "2016-06-24" @default.
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- W2385193724 date "2008-01-01" @default.
- W2385193724 modified "2023-09-24" @default.
- W2385193724 title "Effects of Glucose and Cholesterol on Expression of Angiopoietin-like 3 Gene and Protein in Human Liver Cells" @default.
- W2385193724 hasPublicationYear "2008" @default.
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