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- W2385206038 abstract "Objective: To establish stable gastric epithelium cells model infected by Helicobacter pylori(H.pylori),and to screen and identify H.pylori infection-related microRNAs(miRNAs) so as to investigate the regulatory mechanism of miRNAs.Methods: H.pylori were added to cells at a multiplicity of infection of 100:1.The infection model was monitored by the release of interleukin-8(IL-8) and the expression of COX-2.The expression profile of cellular miRNAs during H.pylori infection were analyzed by microarray(Capi-talBio,Beijing).The significantly altered miRNAs were identified by the quantitative RT-PCR and Northern blot assays.Results: After the incubation of H.pylori with the gastric epithelium cells for 24h,IL-8 release and COX-2 protein expression in cells were detected.The expression of miRNAs could be significantly altered during H.pylori infection by microarray,including the up-regulation of PRE-DICTED-MIR191,miR-155,miR-92b,miR-30b,miR-146a,miR-16 and the down-regulation of miR-181b and miR-324.In consensus with the findings from microarray,miR-155 and miR-146a in infection models increased significantly(P0.01).Conclusion: The upregu-lation of miR-155 and miR-146a in infection models implied that they may be involved in the immune regulation of H.pylori infection." @default.
- W2385206038 created "2016-06-24" @default.
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- W2385206038 date "2011-01-01" @default.
- W2385206038 modified "2023-09-24" @default.
- W2385206038 title "Establishment of Helicobacter pylori infection cell model and identification of infection-associated microRNAs." @default.
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