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- W2385244877 abstract "Objective The microbial pathogen of a Severe Acute Respiratory Syndrome (SARS ) case from Hongkong was isolated , identified and the variance of SARS association-coronavirus was also studied,so as to lay the foundation for the diagnosis, prevention and treatment of the SARS. Methods The throat swab from the patient with SARS was inoculated into cell cultures. The isolate was identified by morphology, serology, RT-PCR amplification and partial sequence analysis. Results A coronavirus (F69) was isolated from the SARS patient. A large quantity of coronavirus-like particles could be observed in the infected cells and supernatants under transmission electron microcope (TEM). Serological assay indicated that the isolated virus was clearly associated with current SARS epidemics. 1635bp of S segments of SARS association-coronaviruses was amplified by RT-PCR and sequenced, sequence analysis showed that the homology of the amplified S fragments to the previously known coronaviruses (HKU、US Urbani and TOR2)was 100%. Compared with GZ01、CUHK and BJ01, there were two nucleotide substitutions in the S protein of F69. Conclusion There are differences between F69 and coronavirus in Guangzhou. The isolated coronavirus was possibly the key causative agent of SARS." @default.
- W2385244877 created "2016-06-24" @default.
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- W2385244877 date "2003-01-01" @default.
- W2385244877 modified "2023-09-28" @default.
- W2385244877 title "Isolation,identification and the variance of a coronavirus from a imputting SARS case" @default.
- W2385244877 hasPublicationYear "2003" @default.
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