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- W2385274489 abstract "Objective To investigate the effect of long-term treatment of combinationof metformin with nitrendipine and atenolol on blood pressure, body weight, levelof insulin resistance (IR), glucose tolerance, lipid metabolism and blood creatininein patients with essential hypertension(EH). Methods One hundred eleven patientswith mild to moderate EH were randomly divided into 2 groups: nitrendiping withatenolol group (group A, n=51) and metformin with nitrendipine and atenolol group(group B, n=60). Treatment period lasted for 14 months. Results The totalresponsive rates were 88.2% (45/51) in group A and 96.7% (58/60) in group B(P0.05). After treatment of combination of nitrendipine with atenolol, bodyweight was significantly increased ( P0.05). Insulin sensitivity index (ISI) wasunchanged (P05), fasting blood glucose was significantly increased (P0.001),low density lipoprotein-cholesterol (LDL-C) was increased markedly (P0.05), highdensity lipoprotein-cholesterol (HDL-C)/LDL-C ratio was decreased markedly(P0.05). After treatment of metformin with nitrendipine and atenolol, body weightwas unchanged, ISI significantly increased (P0.05), both blood glucose, HDL-C/LDL-C ratio and blood creatinine decreased markedly. Compared with treatment ofcombination of nitrendipine with atenolol, treatment of combination of metforminwith nitrendipine and atenolol may control blood pressure more efficiently, preventedbody weight gaining, and has beneficial effect on improving insulin sensitivity,kidney function and carbohydrate metabolism in EH patients. Conclusion Thesesuggested that the combination of metformin with nitrendipine and atenolol maybe a good medicine compounding." @default.
- W2385274489 created "2016-06-24" @default.
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- W2385274489 date "2004-01-01" @default.
- W2385274489 modified "2023-09-25" @default.
- W2385274489 title "Effects of long-term treatment of combination of metformin with antihypertensive drugs on level of insulin resistance and metabolism in patients with essential hypertension" @default.
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