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- W2385275853 abstract "AIM To study the pharmacokinetic character of safflor yellow extraction and hydroxysafflor yellow A (HSYA) in blood stasis rats.METHODS The concentrations of HSYA in plasma of blood stasis rats were analyzed by HPLC-UV method.The pharmacokinetic parameters were calculated by the software DAS 2.0.RESULTS The main pharmacokinetic parameters t(1/2),ρ_(max),t_(max),AUC_(0→6h) and AUC_(0→∞) of safflor yellow extraction and HSYA were(1.38±0.21)and(1.11±0.25)h,(8.05±0.57)and(8.36±1.09)mg·L~(-1),(0.75±0.00)and(1.19±0.55)h,(19.24±1.18) and(22.93±2.19) mg·h·L~(-1),(20.45±1.00) and(23.84±2.00) mg·h·L~(-1),respectively.CONCLUSION The absorption of safflor yellow is faster than HSYA in acute rat model of blood stasis syndrome,but the metabolism of safflor yellow is evidently slower than HSYA in acute rat model of blood stasis syndrome,which shows that the absorption and metabolism of HSYA could be affected by some factors in safflor yellow extraction." @default.
- W2385275853 created "2016-06-24" @default.
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- W2385275853 date "2010-01-01" @default.
- W2385275853 modified "2023-09-22" @default.
- W2385275853 title "Pharmacokinetic character of safflor yellow extraction and hydroxysafflor yellow A in blood stasis rats" @default.
- W2385275853 hasPublicationYear "2010" @default.
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