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- W2385276813 abstract "Objective:To explore the hematopoietic inhibitor of serum IgG from patients with systemic lupus erythematosus and relationship with the apoptosis of CD34~+ cells.Methods:The inhibiting activity to the growth of CFU-E and CFU-GM of normal bone marrow was analysed by in vitro methycelluose culture with normal or SLE serum IgG and CD34~+ cell apoptosis was examined with a kit of programmed cell death assay.Results:The serum IgG of active SLE patients suppressed significantly the colony formation of both CFU-GM and CFU-E of normal bone marrow than inactive SLE,control groups(P0.01).The active patients IgG could bind specifically to normal CD34 hematopoietic cells and induce CD34~+ cells apoptosis,as well as increase the expression of Fas antigen on CD34~+ cells surface.Conclusion:Fas-mediated induction of CD34~+ cells apoptosis by serum IgG from active patients with systemic lupus erythematosus may cause inhibition of hematopoiesis." @default.
- W2385276813 created "2016-06-24" @default.
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- W2385276813 date "2005-01-01" @default.
- W2385276813 modified "2023-09-25" @default.
- W2385276813 title "The hematopoietic inhibitor of serum IgG from patients with systemic lupus erythematosus and relationship with the apoptosis of CD34~+ cells" @default.
- W2385276813 hasPublicationYear "2005" @default.
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