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- W2385279992 abstract "Objective:To prospectively study change of urinary kidney injury molecule-1(KIM-1) level in patients after percutaneous coronary intervention(PCI),and evaluate its early predictive value for contrast-induced nephropathy(CIN).Methods:A total of 160 patients who received coronary angiography(CAG) and PCI were selected.Cases occurring CIN were regard as CIN group(n= 14),paired patients were selected from cases without CIN according to the ratio of 2:1 and regard as control(non CIN group,n = 28).Levels of serum creatinine(SCr)and 24h urinary KIM-1 were compared between two groups before,and 24h,48h and 72h after operation.Results:1.CIN occurred in 14 cases(8.8%);2.Compared with before operation and non CIN group 24h after operation,there was significant increase in urinary KIM-1 level[3.81(3.54,4.32) ng/ml vs.4.33(4.06,4.63) ng/ml vs.5.21(4.86,5.42) ng/ml,P0.05]in CIN group 24h after operation;and SCr level only significantly increased after operation 48h and 72h in CIN group,P0.05 both;3.Pearson correlation analysis indicated that urinary KIM-1 was positively correlated with SCr(r = 0.758,P = 0.002) in CIN group;4.ROC curve indicated that AUC of urinary KIM-1 was 0.839,when cut-off point was 4.595 ng/ml,sensitivity and specificity were 85.7%and71.4%respectively.Conclusion:Urinary kidney injury molecule-1 can reflect change of renal function earlier than creatinine and possesses certain value in early prediction of contrast-induced nephropathy." @default.
- W2385279992 created "2016-06-24" @default.
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- W2385279992 date "2013-01-01" @default.
- W2385279992 modified "2023-09-23" @default.
- W2385279992 title "Change of urinary KIM-1 level after percutaneous coronary intervention and its early predictive value for CIN" @default.
- W2385279992 hasPublicationYear "2013" @default.
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