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- W2385291210 abstract "Objective To evaluate the effects of valsartan and amlodipine used alone or in combination on platelet activation and fibrinolytic activity in patients with essential hypertension (EH).Methods Sixty-nine cases with EH were divided randomly into three groups:valsartan (n=23,80～160 mg/d),amlodipine (n=23,5～10 mg/d),and combined treatment (n=23, valsartan 80 mg/d +amlodipine 5 mg/d).Treatment lasted for 12 weeks.The levels of platelet alpha-granule membrane protein (GMP-140),tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) were measured before and after treatment.Results Levels of GMP-140 and PAI-1 activity were decreased (P0.01),but t-PA activity was increased (P0.01) after treatment in all the three groups. Magnitude of change of GMP-140 and t-PA in the combined treatment group was higher than that either in valsartan or in amlodipine group (P0.05).No significant correlation between the magnitude of decrease or increase of GMP-140,PAI-1 and t-PA activity and that of blood pressures (BP) was found among all the three groups(P0.05 ).Conclusion These findings indicate that valsartan combined with amlodipine treatment has additive effect on inhibiting platelet activation and improving fibrinolytic activity in patients with EH." @default.
- W2385291210 created "2016-06-24" @default.
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- W2385291210 date "2003-01-01" @default.
- W2385291210 modified "2023-09-23" @default.
- W2385291210 title "Effect of combined treatment by valsartan and amlodipine on platelet activation and fibrinolytic activity in hypertensive patients" @default.
- W2385291210 hasPublicationYear "2003" @default.
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