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- W2385299947 abstract "Objective To investigate the effectiveness of combined therapy of fibrin degradation and thrombolysis in rats with focal cerebral ischemia/reperfusion injury. Methods Animal model of focal ischemia/reperfusion in the rat was established by intraluminal suture method and the animals were assigned to Urokinase administration group,DF-521 (Batroxobin) administration group and Urokinase and Batroxobin combined administration group randomly (10 rats in each group). Neurological deficit,infarct volume,histopathology changes and mortality of rats were assessed at 2h after ischemia and 1h,3h,6h,12h,and 48h after reperfusion,respectively. Results Neurological deficit and cerebral hemorrhage transformation in UK treatment group was the most serious (dead in 6 rats,cerebral hemorrhage transformation in 5 rats.) one in all groups. The next was control group (dead in 5 rats,cerebral hemorrhage transformation in 5 rats.). Batroxobin administration group (dead in 4 rats,cerebral hemorrhage transformation in 2 rats.) and the combined administration group (dead in 3 rats,cerebral hemorrhage transformation in 5 rats.) were better than former two groups. Conclusion Our data suggests that combined administration of Urokinase and Batroxobin have neuroprotective effects on ischemic/reperfusion injury,and with no significant cerebral hemorrhage transformation increase compare to Urokinase administration group. Batroxobin may have neuroprotective effect by lessening ischemic/reperfusion injury and it can be safely used." @default.
- W2385299947 created "2016-06-24" @default.
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- W2385299947 date "2005-01-01" @default.
- W2385299947 modified "2023-09-24" @default.
- W2385299947 title "Study on protective effect of combined administration of Urokinase and Batroxobin in rats with focal cerebral ischemia/reperfusion injury" @default.
- W2385299947 hasPublicationYear "2005" @default.
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