Matches in SemOpenAlex for { <https://semopenalex.org/work/W2385334365> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2385334365 abstract "Objective Prepared several small interfering RNAs( siRNA) for AQP4 protein in rat brain by chemical synthesis. The silencing effect of two chains were verified and selected the one which was more effective. Methods Select two different target sequences of the rat according to the AQP4 mRNA. Two siRNAs were synthesised by chemical synthesis,meanwhile negative siRNA was synthesised as control. 18 male adult Wistar rats were randomly divided into negative siRNA injection group,725 line injection group and 1006 line injection group. Corresponding drugs were injected into the left ventricle respectively. All animals were executed after 6 hours. The protein expression of AQP4 was detected by immunohistochemical staining and the AQP4mRNA expression was detected by in situ hybridization. Results 6 hours after injection,the expression of AQP4 protein and AQP4 mRNA of brain in the 725 line injection group were significantly lower than those of the 1006 line injection group and the negative siRNA injection group( P 0. 05). Conclusion 725 line injection could effectively silence the expression of AQP4 in rat brain in 6 hours." @default.
- W2385334365 created "2016-06-24" @default.
- W2385334365 creator A5054446611 @default.
- W2385334365 date "2014-01-01" @default.
- W2385334365 modified "2023-09-23" @default.
- W2385334365 title "Test and Selection of Effect of Silencing AQP4 Gene with Chemical Synthesis siRNA" @default.
- W2385334365 hasPublicationYear "2014" @default.
- W2385334365 type Work @default.
- W2385334365 sameAs 2385334365 @default.
- W2385334365 citedByCount "0" @default.
- W2385334365 crossrefType "journal-article" @default.
- W2385334365 hasAuthorship W2385334365A5054446611 @default.
- W2385334365 hasConcept C104317684 @default.
- W2385334365 hasConcept C105580179 @default.
- W2385334365 hasConcept C119056186 @default.
- W2385334365 hasConcept C142724271 @default.
- W2385334365 hasConcept C150194340 @default.
- W2385334365 hasConcept C153911025 @default.
- W2385334365 hasConcept C185592680 @default.
- W2385334365 hasConcept C204232928 @default.
- W2385334365 hasConcept C22615655 @default.
- W2385334365 hasConcept C54009773 @default.
- W2385334365 hasConcept C55493867 @default.
- W2385334365 hasConcept C71924100 @default.
- W2385334365 hasConcept C81439078 @default.
- W2385334365 hasConcept C86803240 @default.
- W2385334365 hasConcept C98274493 @default.
- W2385334365 hasConceptScore W2385334365C104317684 @default.
- W2385334365 hasConceptScore W2385334365C105580179 @default.
- W2385334365 hasConceptScore W2385334365C119056186 @default.
- W2385334365 hasConceptScore W2385334365C142724271 @default.
- W2385334365 hasConceptScore W2385334365C150194340 @default.
- W2385334365 hasConceptScore W2385334365C153911025 @default.
- W2385334365 hasConceptScore W2385334365C185592680 @default.
- W2385334365 hasConceptScore W2385334365C204232928 @default.
- W2385334365 hasConceptScore W2385334365C22615655 @default.
- W2385334365 hasConceptScore W2385334365C54009773 @default.
- W2385334365 hasConceptScore W2385334365C55493867 @default.
- W2385334365 hasConceptScore W2385334365C71924100 @default.
- W2385334365 hasConceptScore W2385334365C81439078 @default.
- W2385334365 hasConceptScore W2385334365C86803240 @default.
- W2385334365 hasConceptScore W2385334365C98274493 @default.
- W2385334365 hasLocation W23853343651 @default.
- W2385334365 hasOpenAccess W2385334365 @default.
- W2385334365 hasPrimaryLocation W23853343651 @default.
- W2385334365 hasRelatedWork W2350597139 @default.
- W2385334365 hasRelatedWork W2352296454 @default.
- W2385334365 hasRelatedWork W2354189228 @default.
- W2385334365 hasRelatedWork W2369480742 @default.
- W2385334365 hasRelatedWork W2369546314 @default.
- W2385334365 hasRelatedWork W2371431148 @default.
- W2385334365 hasRelatedWork W2372445089 @default.
- W2385334365 hasRelatedWork W2372516439 @default.
- W2385334365 hasRelatedWork W2372637044 @default.
- W2385334365 hasRelatedWork W2382053248 @default.
- W2385334365 hasRelatedWork W2385343104 @default.
- W2385334365 hasRelatedWork W2385724393 @default.
- W2385334365 hasRelatedWork W2390855408 @default.
- W2385334365 hasRelatedWork W2392946654 @default.
- W2385334365 hasRelatedWork W2394112910 @default.
- W2385334365 hasRelatedWork W2404196698 @default.
- W2385334365 hasRelatedWork W287471173 @default.
- W2385334365 hasRelatedWork W2895635399 @default.
- W2385334365 hasRelatedWork W3029174930 @default.
- W2385334365 hasRelatedWork W2037560865 @default.
- W2385334365 isParatext "false" @default.
- W2385334365 isRetracted "false" @default.
- W2385334365 magId "2385334365" @default.
- W2385334365 workType "article" @default.