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- W2385344742 abstract "Objective To investigate the role of soluble vascular cell adhesion molecule-1(sVCAM-1) in type 2 diabetes complicated with coronary heart disease(CHD),and elucidate the mechanism of the protective effects of fluvastatin intervention on these patients.Methods 40 normal subjects,40 type 2 diabetics without CHD and 40 type 2 diabetics with CHD underwent examinations of body mess index(BMI),blood lipids,blood sugar and HOMA-IR,and their sVCAM-1 was determined by ELISA before fluvastatin treatment.All diabetics received fluvastatin intervention for 24 weeks prior to a second sVCAM-1 detection by ELISA so as to establish contrast of therapeutic stages and research on the correlations between these indices.Simultaneously,their FPG,2hPG,HOMA-IR,HbA1c,TG,TC,LDL-C,HDL-C,and BMI were measured.The results of determination were analyzed statistically.Results The serum VCAM-1 in type 2 diabetics with CHD was higher than that in type 2 diabetics without CHD and healthy controls.Serum VCAM-1 was correlated positively with FPG,2hPG,HOMA-IR,HbA1c,TG,TC,LDL-C,BMI,and correlated negatively with HDL-C.After fluvastatin treatment,the levels of serum sVCAM-1 of all diabetics were reduced to a certain degree.Conclusion The results indicate that sVCAM-1 plays an important role in insulin resistance and the pathogenesis of type 2 diabetics complicated with CHD.The protective effects of fluvastatin on blood vessel partly attribute to its lowering of serum sVCAM-1.Levels of serum sVCAM-1 can serve as an indication in the evaluation and therapy of type 2 diabetics with CHD." @default.
- W2385344742 created "2016-06-24" @default.
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- W2385344742 date "2008-01-01" @default.
- W2385344742 modified "2023-09-26" @default.
- W2385344742 title "Clinical research on the level of soluble vascular cell adhesion molecule-1 and the effect of fluvastatin intervention on it in type 2 diabetes mellitus complicated with coronary heart disease" @default.
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