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- W2385357426 abstract "Objective To investigate the expression of Twist protein in esophageal squamous cell carcinoma(ESCC) and the significance in determining the biological behaviors of the tumor by its function on E-cadherin(E-cad) and vascular endothelial growth factor(VEGF).Methods Twist,E-cad and VEGF proteins expression were detected by SP immunohistochemistry method in 54 cases of ESCC(controlled with 20 cases of paraneoplastic tissue specimens).Results The positive rate of Twist protein was higher in ESCC(70.1%) than that in paraneoplastic tissues(15%,P=0.000).The expression of Twist protein in the groups of adventitia invasion,lymph node metastasis and stage Ⅲ were significantly higher than that in the groups of non-adventitia invasion,non-lymph node metastasis and stageⅠ~Ⅱrespectively(P0.05).Negative correlation was obtained between the expression of Twist and E-cad proteins(r=-0.401,P=0.003),while positive correlation was gained between the expression of Twist and VEGF proteins(r=0.526,P=0.000).Conclusions The over-expression of Twist protein in ESCC might play an important role in the invasiveness and metastasis of the tumor by down-regulating the expression of E-cadherin and up-regulating the expression of VEGF." @default.
- W2385357426 created "2016-06-24" @default.
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- W2385357426 date "2008-01-01" @default.
- W2385357426 modified "2023-09-26" @default.
- W2385357426 title "The Study on Significance of Twist,E-cadherin and VEGF Proteins Expression in Esophageal Squamous Cell Carcinoma" @default.
- W2385357426 hasPublicationYear "2008" @default.
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