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- W2385358089 abstract "AIM This study was to explore possible interactions among genetic risk factors for stroke risk.Methords We randomly recruited a total of 4000 ethnically identical participants from 7 clini- cal centers and examined 8 variants in 5 candidate genes for stroke risk.Interactions were explored by using the methods of generalized multifactor dimensionality reduction(GMDR).Results The GMDR analysis showed a significant gene-gene interaction among Notch3 C381T,MTHFR C677T and ALOXSAP T2354. The combination of MTHFR 677TT/ALOX5AP 2354AA/Notch3 381TT contributed to a significantly higher risk of thrombotic stroke(OR,3.720;95% CI,1.235 to 11.209;P0.05)than did any one of the vari- ant.Conclusion The three-loci interaction significantly confers higher risk for thrombotic stroke.Such combinational analysis could be helpful to explore genetic risk factors of common complex diseases." @default.
- W2385358089 created "2016-06-24" @default.
- W2385358089 creator A5023391846 @default.
- W2385358089 date "2008-01-01" @default.
- W2385358089 modified "2023-09-22" @default.
- W2385358089 title "Interaction of Variants in Notch3 gene,MTHFR gene and ALOX5AP gene Significantly Increase the Risk for Thrombotic Stroke" @default.
- W2385358089 hasPublicationYear "2008" @default.
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