Matches in SemOpenAlex for { <https://semopenalex.org/work/W2385364178> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2385364178 abstract "Objective:To investigate the effect of MDR1 siRNA on multidrug resistance(MDR1)of Human carcinoma of the tongue cells.Method:Human multidrug-resistant Human carcinoma of the tongue cell line TCA8113 over expressing mdr1 gene was used as the target.The siRNA speciafically targeting mdr1 gene was chemically synthesized and identified,then was transfected into TCA8113 cells with RNAi-MATE.Clone cells were screened by G418.The silencing efficiency of siRNA was evaluated by the inhibition of mdr1 mRNA expression measured with RT-PCR and the inhabition of P-glycoprotein(P-gp)expression with immunohistochemical analysis.The sensitivity of the cells to PYM,Cisplatin(DDP)and Carboplatin(CBP)was detected with a MTT colorimetric assay.Result:The expression of MDR1 mRNA and P-gp in positive clone cells(TCA8113)were all inhibited.IC50 of DDP,CBP and PYM for TCA8113 cells were 3.43 μmol/L,1.72 μmol/L and 1.05 μmol/L,respectively(P 0.01).Conclusion:Stable trasfection of plasmid vector encoding MDR1 siRNA can speciafically depress the expression of mdr1 gene and its product P-gp in drug-resistant TCA8113 cells and reverse multidrug resistance to chemotherapeutical agents." @default.
- W2385364178 created "2016-06-24" @default.
- W2385364178 creator A5074577614 @default.
- W2385364178 date "2010-01-01" @default.
- W2385364178 modified "2023-09-26" @default.
- W2385364178 title "Effect of MDR1 siRNA on drug resistance of human carcinoma of the tongue cell line TCA8113" @default.
- W2385364178 hasPublicationYear "2010" @default.
- W2385364178 type Work @default.
- W2385364178 sameAs 2385364178 @default.
- W2385364178 citedByCount "0" @default.
- W2385364178 crossrefType "journal-article" @default.
- W2385364178 hasAuthorship W2385364178A5074577614 @default.
- W2385364178 hasConcept C104317684 @default.
- W2385364178 hasConcept C105580179 @default.
- W2385364178 hasConcept C114851261 @default.
- W2385364178 hasConcept C119056186 @default.
- W2385364178 hasConcept C133936738 @default.
- W2385364178 hasConcept C153911025 @default.
- W2385364178 hasConcept C166703698 @default.
- W2385364178 hasConcept C2776694085 @default.
- W2385364178 hasConcept C2778239845 @default.
- W2385364178 hasConcept C2778707650 @default.
- W2385364178 hasConcept C2780783641 @default.
- W2385364178 hasConcept C502942594 @default.
- W2385364178 hasConcept C54009773 @default.
- W2385364178 hasConcept C54355233 @default.
- W2385364178 hasConcept C55493867 @default.
- W2385364178 hasConcept C67705224 @default.
- W2385364178 hasConcept C81089528 @default.
- W2385364178 hasConcept C81885089 @default.
- W2385364178 hasConcept C86803240 @default.
- W2385364178 hasConceptScore W2385364178C104317684 @default.
- W2385364178 hasConceptScore W2385364178C105580179 @default.
- W2385364178 hasConceptScore W2385364178C114851261 @default.
- W2385364178 hasConceptScore W2385364178C119056186 @default.
- W2385364178 hasConceptScore W2385364178C133936738 @default.
- W2385364178 hasConceptScore W2385364178C153911025 @default.
- W2385364178 hasConceptScore W2385364178C166703698 @default.
- W2385364178 hasConceptScore W2385364178C2776694085 @default.
- W2385364178 hasConceptScore W2385364178C2778239845 @default.
- W2385364178 hasConceptScore W2385364178C2778707650 @default.
- W2385364178 hasConceptScore W2385364178C2780783641 @default.
- W2385364178 hasConceptScore W2385364178C502942594 @default.
- W2385364178 hasConceptScore W2385364178C54009773 @default.
- W2385364178 hasConceptScore W2385364178C54355233 @default.
- W2385364178 hasConceptScore W2385364178C55493867 @default.
- W2385364178 hasConceptScore W2385364178C67705224 @default.
- W2385364178 hasConceptScore W2385364178C81089528 @default.
- W2385364178 hasConceptScore W2385364178C81885089 @default.
- W2385364178 hasConceptScore W2385364178C86803240 @default.
- W2385364178 hasLocation W23853641781 @default.
- W2385364178 hasOpenAccess W2385364178 @default.
- W2385364178 hasPrimaryLocation W23853641781 @default.
- W2385364178 hasRelatedWork W2171021566 @default.
- W2385364178 hasRelatedWork W2351610978 @default.
- W2385364178 hasRelatedWork W2355476010 @default.
- W2385364178 hasRelatedWork W2355579673 @default.
- W2385364178 hasRelatedWork W2358741989 @default.
- W2385364178 hasRelatedWork W2360383735 @default.
- W2385364178 hasRelatedWork W2362528840 @default.
- W2385364178 hasRelatedWork W2391995489 @default.
- W2385364178 hasRelatedWork W2401207769 @default.
- W2385364178 hasRelatedWork W2409431860 @default.
- W2385364178 hasRelatedWork W2411654120 @default.
- W2385364178 hasRelatedWork W2414552021 @default.
- W2385364178 hasRelatedWork W2419151126 @default.
- W2385364178 hasRelatedWork W2419603381 @default.
- W2385364178 hasRelatedWork W3029848413 @default.
- W2385364178 hasRelatedWork W3031206425 @default.
- W2385364178 hasRelatedWork W3031755134 @default.
- W2385364178 hasRelatedWork W3120162272 @default.
- W2385364178 hasRelatedWork W3028807658 @default.
- W2385364178 hasRelatedWork W3030113982 @default.
- W2385364178 isParatext "false" @default.
- W2385364178 isRetracted "false" @default.
- W2385364178 magId "2385364178" @default.
- W2385364178 workType "article" @default.