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- W2385373669 abstract "To investigate the protective effect of fluconazole and itraconazole for the reactivated toxoplasmosis in mice,ICR mice infected with Toxoplasma gondii(T.gondii)for two months were grouped as follows:cyclophosphamide(CTX) treatment;cyclophosphamide combined with fluconazole(CTX+F),cyclophosphamide with itraconazole(CTX+I),and cyclophosphamide with azithromycin(CTX+A).Normal mice only given with CTX and mice with T.gondii infection were set up as control.The CTX doses mouse got was 100mg/kg·d by intraperitoneal injection except the infection(In)group.At the same time,mice from CTX+F and CTX+I were administrated fluconazole or itraconazole at various concentrations of 20mg/kg·d,30mg/kg·d and 40mg/kg·d,respectively,and the concentration of azithromycin got by mice from CTX+A group was 250mg/kg·d.The medicines were administrated for continuous 14days.At the end of the experiment,the mice from CTX group were dead;however,the mice from CTX+A group,CTX group and In group were survival,and the survival rate between CTX+A and CTX was significant deviation(P=0.016).Survival deviation of mice was very significant,which came from CTX group,CTX +F group,CTX+I group,and CTX+A group(P=0.000).Azithromycin was the best in the three drugs,among which fluconazole effect was better than itraconazole(P=0.000).However,survival rate resulted in by different fluconazole or itraconazole dose was not significant deviation.Compared CTX group with others,the number of cysts in the brain were obvious increased(P=0.001),but the number of cysts was no statistical difference among CTX+A,CTX+ I,CTX+F,and In groups.Although there were different cysts in three concentrations of CTX+F and CTX+I groups,there was no statistically significant.It's suggested that fluconazole could make some protection for the reactivated acute toxoplasmosis in mice,and it could be an alternative to T.gondii infected patients who were immunity suppression or with opportunistic fungal infection." @default.
- W2385373669 created "2016-06-24" @default.
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- W2385373669 date "2013-01-01" @default.
- W2385373669 modified "2023-09-23" @default.
- W2385373669 title "Antifungal therapy for the relapse of acute toxoplasmosis in mice" @default.
- W2385373669 hasPublicationYear "2013" @default.
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