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- W2385381640 abstract "Objective To investigate the influence of PI3K p85α on the invasion and metastasis of colorectal cancer.Methods The expression of PI3K p85α was evaluated in 85 normal colorectal tissue,colorectal adenoma,primary colorectal carcinoma and metastatic colorectal carcinoma specimens using immunohistochemical staining,and the relationship between the expression of PI3K p85α protein and the clinicopathological factors was analyzed.The PI3Kp85α/RNAi transfected cells(PI3K p85α/RNAi-Lovo) were cultured in RPMI1640,supplemented with 10% fetal calf serum and 500 g/ml G418.The cells were subjected to transwell assay and wound closure assay to determine the invasion and migration of PI3K p85α-depleted cells and the control cells.Expression of MMP-2 was detected by gelatin-zymography assays.Results The expression of PI3K p85α protein was significantly correlated with the progression of colorectal cancer(P0.05).The invasion and metastatic ability of PI3K p85α/RNAi-Lovo were significantly lower than the control cells.Gelatin-zymography analysis showed that the expression and activity of MMP-2 was significantly suppressed in PI3Kp85α-knockdown cells than in the control cells.Conclusion PI3K p85α may play an important role in modulating human colorectal carcinoma cells invasion and metastasis,and PI3K p85α gene silencing can inhibit human colorectal cancer cell invasion and the activity of MMP-2.PI3Kp85α may affect invasion and metastasis of human colorectal carcinoma cells via the regulation of the activity of MMP-2." @default.
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- W2385381640 date "2011-01-01" @default.
- W2385381640 modified "2023-09-26" @default.
- W2385381640 title "PI3K p85α expression and its role in the progression of colorectal cancer invasion and metastasis" @default.
- W2385381640 hasPublicationYear "2011" @default.
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