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- W2385405464 abstract "Objective To evaluate the safety and immune protection efficacy of the living attenuated Japanese encephalitis(JE)vaccine and the purified Vero cell-derived Japanese encephalitis vaccine(Vero cell JE vaccine).Methods Two groups of healthy infants,the 8~20 months infants without initial immunization of JE vaccination(basic immunization group)and the infants aged 1.5 to 3 years with previous JE vaccination(boosting immunization group)were selected as the observation subjects in Yuanjiang City and Hengdong County.Infants from Yuanjiang City received the living attenuated JE vaccine and infants from Hengdong County received the Vero cell JE vaccine.Part of the two groups infants from different city and county were tested for anti-JE neutralizing antibody before and 1-month after vaccination and their adverse reactions were observed.Results The total rates of adverse reactions of living attenuated JE vaccine and Vero cell JE vaccine were5.2% and 8.8% respectively.Febrile reaction was the main adverse reaction,accounted for 95.4% and 92.3% of these 2 kinds of vaccine,and disappeared after 72 hours.Of the living attenuated JE vaccine the antibody positive rate was 82.5% after basic immunization,and the geometric mean antibody titer(GMT)was 1:23.1.The antibody positive rate was 93.2% after boosting immunization,and the GMT was 1:28.6.Of the living attenuated JE vaccine the antibody positive rate was 83.2% after basic immunization,and the GMT was 1:25.1.The antibody positive rate was 93.7% after boosting immunization,and the GMT was 1:32.4.Conclusion Both the living attenuated JE vaccine and Vero cell JE vaccine are safe and effective,and should be recommended in the control and prevention of Japanese encephalitis." @default.
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- W2385405464 date "2007-01-01" @default.
- W2385405464 modified "2023-09-23" @default.
- W2385405464 title "Efficacy and Safety Evaluation of Two Kinds of Japanese Encephalitis Vaccine" @default.
- W2385405464 hasPublicationYear "2007" @default.
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