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- W2385406193 abstract "Objective:To study the expression and significance of CD68,α-SMA in senile patients with coronary ahtherosclerotic(AS) lesion and diffuse intimal thickening(DIT),and explore the correlation between the expression of CD68,α-SMA and the lesion types of coronary AS,the degree of luminal stenosis. Method:Three hundred and twelve coronary artery tissue samples were selected from 53 autopsy cases.DIT and AS types were diagnosed by optical microscope.CD68 positive macrophages,α-SMA positive area(%),lumen stenosis,lipid necrotic core(NC) and calcifying matrix area(%) were detected by immunohistochemistry and the Scion image software system. Result:①With the progress of AS lesion and the aggravation of luminal stenosis,the expression of CD68 macrophage increased(r=0.351,0.197,P0.01),while α-SMA positive area decreased(r=-0.494,-0.362,P0.01),and there were significant differences between early and advanced lesions(P0.05).②The expression of CD68 macrophage and α-SMA positive area had significant differences among different lesion types,degree of luminal stenosis as well as cholesterol groups(P0.05). Conclusion:Increased CD68 positive macrophages and decreased SMA positive area could promote the senile coronary lesions all along." @default.
- W2385406193 created "2016-06-24" @default.
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- W2385406193 date "2012-01-01" @default.
- W2385406193 modified "2023-09-25" @default.
- W2385406193 title "Expression and significance of CD68,α-SMA in senile coronary atherosclerotic lesion" @default.
- W2385406193 hasPublicationYear "2012" @default.
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