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- W2385409504 abstract "Aim:To explore the toxic and side effects on central nervous system in mice following intravenous administration of ornidazole enantiomers.Methods:The hypnotic activity,the sleeping synergic action with thiopentone and locomotor activity were performed in order to observe the sedative effects of the ornidazole enantiomers in mice.The anticonvulsive activities of ornidazole enantiomers were investigated in mice of dimefline,strychnine,isoniazide and thiosemicarbazide-induced seizures.Results:(R)-ornidazole(160 mg/kg,iv) had hypnotic effect.(R)-ornidazole produced a dose-dependent prolongation of thiopentone sleeping time and suppression of locomotor activity.(S)-ornidazole had weaker sedative effects.(S)-or(R)-ornidazole had anticonvulsive effects to different extents in the experimental animal models of epilepsy induced by dimefline,strychnine,isoniazide and thiosemicarbazide in mice.(R)-ornidazole(80 and 160 mg/kg,iv)showed protection against seizures induced by dimefline and thiosemicarbazide,but(S)-ornidazole hardly had the anticonvulsive effect.The results indicated that the depressant and anticonvulsive effects of(R)-ornidazole were stronger than those of(S)-ornidazole.Conclusion:There exists a difference in the action on the central nervous system between(S)-and(R)-ornidazole.(R)-ornidazole has much stronger central inhibition than(S)-ornidazole." @default.
- W2385409504 created "2016-06-24" @default.
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- W2385409504 date "2008-01-01" @default.
- W2385409504 modified "2023-09-25" @default.
- W2385409504 title "Comparative study of ornidazole enantiomers on the toxic and side effects to central nervous system in mice" @default.
- W2385409504 hasPublicationYear "2008" @default.
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