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- W2385412988 abstract "Objective:Study of the biological effect of soluble gp130(sgp130)molecule on the system of interlukin 6(IL 6)/IL 6 recepter on the basis of successful cloning,expression and purification of sgp130 molecule.Methods:The membrane gp130 transduced cell line BAF 130,human multiple myeloma(MM)cell line XG4 CNTF and freshly isolated MM cells were used for biological assa by means of 3HTdR incorporation in order to observe biological effect of sgp130 on IL 6 activity to these cells.Results:The results demonstrated that sgp130 displayed inhibitory role in the proliferation of BAF 130 cell line induced by IL 6 and soluble IL 6 recepter.In addition,sgp130 also showed the inhibitory effects on the proliferation,of XG4 CNTF cell lne stimulated by IL 6 and freshly isolated MM cells.Conclusion:These results suggested that sgp130 was an antagonist of IL 6." @default.
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- W2385412988 date "1999-01-01" @default.
- W2385412988 modified "2023-09-25" @default.
- W2385412988 title "Study of biological effect of soluble gp130(sgp130)molecule on the system of interlukin 6/interlukin 6 recepter" @default.
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