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- W2385441104 abstract "Objective To investigate the characteristic and clinical significance of chromosomal karyotype analysis to malignant hematologic diseases. Methods A total of 183 patients with malignant hematologic diseases were enrolled from August 2006 to May 2011 and were subjected to bone marrow smear and bone marrow biopsy for further chromosomal karyotype analysis prior to the treatment. Results Of 183 patients enrolled, abnormal chromosomal karyotypes were detected in 103 cases. The diagnoses were consisted of acute leukemia (n=40), of which plasma cell leukemia (n=1), lymphoma cell leukemia (n=2) and chronic myelocytic leukemia (n=25) were identified; myelodysplastic syndrome (n=22); multiple myeloma (n=6); myeloproliferative disease (n=6) and aplastic anemia (n=1). Based on the FAB classification,75% of patients with M3 presented t(15;17) translocation, those with M6 were associ- ated with No. 1 chromosome anomaly, 60% with M2 showed t(8;21) translocation and 92% with chronic myelocytic leukemia were shown to have t(9;22) translocation. Conclusion Chromosomal karyotype analysis is indispensible to the diagnosis and classification of malignant hematologic diseases." @default.
- W2385441104 created "2016-06-24" @default.
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- W2385441104 date "2012-01-01" @default.
- W2385441104 modified "2023-09-28" @default.
- W2385441104 title "Chromosomal karyotype analysis in 183 patients with malignant hematologic diseases" @default.
- W2385441104 hasPublicationYear "2012" @default.
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