Matches in SemOpenAlex for { <https://semopenalex.org/work/W2385442553> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2385442553 abstract "AIM: To explore the protective effects and mechanism of astragalus injection on asthmatic rats. METHODS: OVA was injected intraperitoneally and inhaled to produce the asthmatic rat models. Forty rats were randomly divided into five groups: control group, asthma group and astragalus groups of high, medium and low dose. The concentration of IL-5 in BALF and the expression of IL-5 mRNA, phospho-p38 MAPK in lung tissue were respectively measured by ELISA, in situ hybridization staining and Western blot. The number of inflammatory cell in BALF was calculated and histopathology changes were observed. RESULTS: The number of inflammatory cell and the concentration of IL-5 in BALF and the expression of IL-5 mRNA, phospho-p38 MAPK in lung tissue were higher in asthmatic rat group than those in normal control(P0.01); and those in astragalus rat group were lower than in asthmatic rat group(P0.01). The histopathology damage was alleviated in astragalus rat group. The efficacies in the astragalus groups of high, medium and low dose were similar, showing no insignificant difference among them. The expression of phospho-p38 MAPK has positive correlation with the number of eosinophil and the concentration of IL-5, the expression of IL-5 mRNA(r=0.62,0.69,0.74,P0.01). CONCLUSION: p38 MAPK may play a role in pathological process of asthma. Astragalus could effectively treat asthma by inhibiting the expression of phospho-p38 MAPK and IL-5, and decreasing the number of inflammatory cells." @default.
- W2385442553 created "2016-06-24" @default.
- W2385442553 creator A5027092697 @default.
- W2385442553 date "2008-01-01" @default.
- W2385442553 modified "2023-09-23" @default.
- W2385442553 title "Protective effects and mechanism of astragalus injection on asthmatic rats" @default.
- W2385442553 hasPublicationYear "2008" @default.
- W2385442553 type Work @default.
- W2385442553 sameAs 2385442553 @default.
- W2385442553 citedByCount "0" @default.
- W2385442553 crossrefType "journal-article" @default.
- W2385442553 hasAuthorship W2385442553A5027092697 @default.
- W2385442553 hasConcept C104317684 @default.
- W2385442553 hasConcept C105580179 @default.
- W2385442553 hasConcept C126322002 @default.
- W2385442553 hasConcept C134018914 @default.
- W2385442553 hasConcept C142724271 @default.
- W2385442553 hasConcept C16685009 @default.
- W2385442553 hasConcept C188947578 @default.
- W2385442553 hasConcept C203014093 @default.
- W2385442553 hasConcept C204787440 @default.
- W2385442553 hasConcept C2776042228 @default.
- W2385442553 hasConcept C2776415932 @default.
- W2385442553 hasConcept C2777037409 @default.
- W2385442553 hasConcept C2780798337 @default.
- W2385442553 hasConcept C51551487 @default.
- W2385442553 hasConcept C544855455 @default.
- W2385442553 hasConcept C55493867 @default.
- W2385442553 hasConcept C57074206 @default.
- W2385442553 hasConcept C62478195 @default.
- W2385442553 hasConcept C71924100 @default.
- W2385442553 hasConcept C81439078 @default.
- W2385442553 hasConcept C86803240 @default.
- W2385442553 hasConcept C98274493 @default.
- W2385442553 hasConceptScore W2385442553C104317684 @default.
- W2385442553 hasConceptScore W2385442553C105580179 @default.
- W2385442553 hasConceptScore W2385442553C126322002 @default.
- W2385442553 hasConceptScore W2385442553C134018914 @default.
- W2385442553 hasConceptScore W2385442553C142724271 @default.
- W2385442553 hasConceptScore W2385442553C16685009 @default.
- W2385442553 hasConceptScore W2385442553C188947578 @default.
- W2385442553 hasConceptScore W2385442553C203014093 @default.
- W2385442553 hasConceptScore W2385442553C204787440 @default.
- W2385442553 hasConceptScore W2385442553C2776042228 @default.
- W2385442553 hasConceptScore W2385442553C2776415932 @default.
- W2385442553 hasConceptScore W2385442553C2777037409 @default.
- W2385442553 hasConceptScore W2385442553C2780798337 @default.
- W2385442553 hasConceptScore W2385442553C51551487 @default.
- W2385442553 hasConceptScore W2385442553C544855455 @default.
- W2385442553 hasConceptScore W2385442553C55493867 @default.
- W2385442553 hasConceptScore W2385442553C57074206 @default.
- W2385442553 hasConceptScore W2385442553C62478195 @default.
- W2385442553 hasConceptScore W2385442553C71924100 @default.
- W2385442553 hasConceptScore W2385442553C81439078 @default.
- W2385442553 hasConceptScore W2385442553C86803240 @default.
- W2385442553 hasConceptScore W2385442553C98274493 @default.
- W2385442553 hasOpenAccess W2385442553 @default.
- W2385442553 hasRelatedWork W170938708 @default.
- W2385442553 hasRelatedWork W2316242042 @default.
- W2385442553 hasRelatedWork W2349282109 @default.
- W2385442553 hasRelatedWork W2352286015 @default.
- W2385442553 hasRelatedWork W2368066006 @default.
- W2385442553 hasRelatedWork W2397878496 @default.
- W2385442553 hasRelatedWork W2403401853 @default.
- W2385442553 hasRelatedWork W2407255041 @default.
- W2385442553 hasRelatedWork W2412327492 @default.
- W2385442553 hasRelatedWork W2415623674 @default.
- W2385442553 hasRelatedWork W2994625525 @default.
- W2385442553 hasRelatedWork W3029143465 @default.
- W2385442553 hasRelatedWork W3029231273 @default.
- W2385442553 hasRelatedWork W3029836709 @default.
- W2385442553 hasRelatedWork W3030310998 @default.
- W2385442553 hasRelatedWork W3031384427 @default.
- W2385442553 hasRelatedWork W3031964800 @default.
- W2385442553 hasRelatedWork W3032678891 @default.
- W2385442553 hasRelatedWork W3149011339 @default.
- W2385442553 hasRelatedWork W3194033001 @default.
- W2385442553 isParatext "false" @default.
- W2385442553 isRetracted "false" @default.
- W2385442553 magId "2385442553" @default.
- W2385442553 workType "article" @default.