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- W2385444311 abstract "Objective: This study investigated effects of exogenous nucleotides on proliferation and migration of a normal rat small intestinal epithelial cell line,IEC-6. Method: The concentration-effects and interaction of exogenous nucleotides on proliferation of IEC-6 were measured by MTT. Migration of IEC-6 after wounded was determined by an in vitro model of intestinal epithelial restitution of IEC-6 monolayer, Expression of TGFβwas detected by immnohistochemistry Results: AMP and GMP remarkably inhibited proliferation of IEC-6 with concentration--dependent way respectively at 30μmol/L or 150μmol/L and more. CMP, UMP and nucleotides mixture could not enhance or inhibit the growth except for CMP inhibiting proliferation at very high concentration (1440μmol/L). In contrast, However, CMP, especially UMP, could remarkably abolished the proliferation-inhibiting effects of AMP or GMP on the cell, when supplemented with the AMP or GMP. Nucleotides mixture significantly facilitated migration of IEC-6 after wounded but failed to promote the expression of TGFβ.Conclusion: Purine nucleotides inhibited proliferation of IEC-6, pyrimidine nucleotides could abolish the inhibitive effects of purine nucleotides. Nucleotides mixture promoted migration of IEC-6 after wounded by a TGFβ-independented way." @default.
- W2385444311 created "2016-06-24" @default.
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- W2385444311 date "2003-01-01" @default.
- W2385444311 modified "2023-09-25" @default.
- W2385444311 title "Effects of Exogenous Nucleotides on the Proliferation and Migration of Intestinal Epithelial Cells" @default.
- W2385444311 hasPublicationYear "2003" @default.
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