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- W2385460845 abstract "OBJECTIVE To establish an HPLC method for simultaneously determining the concentration of Propofol and its prodrug HX0969w in rabbit plasma.METHODS HPLC method was adopted.An Agilent eclipse plus C18 column(150 mm×4.6 mm,5 μm) was used.The mobile phase consisted of methanol-water-10% tetrabutyl ammonium hydroxide(70:29:1,with 0.1% triethylamine,adding phosphoric acid to adjust pH7.0).The flow rate was 1 mL·min-1,the detection wavelength was 260 nm for HX0969w and 272 nm for propofol.RESULTS The linear range of HX0969w was 46.5-2973.6 μg·mL-1(r=0.9997),the average recovery was 95.97 %.The linear range of propofol was 9.4-601.0 μg·mL-1(r=0.9993),the average recovery was 98.08%.The intra and inter-assay precision for this analysis were less than 4.22% and 7.92%,respectively.CONCLUSION The method is simple,accurate,rapid,and can be used for the simultaneous determination of propofol and its prodrug HX0969w in plasma.Thus the method is suitable for pharmacokinetic studies of HX0969w and the content detection of the raw material or preparation." @default.
- W2385460845 created "2016-06-24" @default.
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- W2385460845 date "2011-01-01" @default.
- W2385460845 modified "2023-09-24" @default.
- W2385460845 title "Simultaneous determination of Propofol and its prodrug HX0969w in rabbit plasma by HPLC" @default.
- W2385460845 hasPublicationYear "2011" @default.
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