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- W2385467479 abstract "Objective:To investigate the effect of the combined therapy of HCG and human immunoglobulin G on local decidual Th1/Th2 type cytokines of bromocriptine induced aborting rats and its influence on pregnancy's outcome.Methods: Rat models were induced by hypodermic injection of bromocriptine on the 6th 、7th 、8th day of pregnancy,and then divided into four groups: model group(group A),HCG group(group B),HCG and human immunoglobulin G group(group C);normal pregnant rats(D),On the 14th day after pregnancy,all rats were sacrificed to observe the fetes.Deciduas near the embryo were collected and mingled with the RIPA and PMSF,then grounded in a glass container for centrifugation,the supernatant were conserved at-80℃ for further use.The TNF-α、IFN-γ、IL-4 、IL-10's level of the supernatant were detected by ELISA method.Result:Fetal absorption rate of group A was significant higher than the other three groups(P0.05),the rate of group B was also significant higher than group B and C(P0.05).Compared with group A,Th1 type cytokines(TNF-α,FN-γ,) were significantly decreased in group B,C and D(P 0.05),while Th2 type cytokines(IL-4 and IL-10) all increased in the three groups(P0.5).Conclusions: The combined therapy of HCG and immunoglobulin G can improve the development of fetus by up-regulating local deciduas IL-10 levels." @default.
- W2385467479 created "2016-06-24" @default.
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- W2385467479 date "2012-01-01" @default.
- W2385467479 modified "2023-09-23" @default.
- W2385467479 title "Effect of HCG combining with immunoglobulin G on maternal-fetal interface's Th1/Th2 type cytokines of aborting rats induced by bromocriptine" @default.
- W2385467479 hasPublicationYear "2012" @default.
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