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- W2385485792 abstract "Objective To investigate the effects of IL- 6 on the expression of MMP- 3 mRNA and proteins in HPDLC,so as to learn about the role of IL - 6 in ECM metabolism. Methods HPDLC were treated with IL - 6 at varying concentrations (1 -100U/ml) for 24h and 48h prior to analysis at either transcript or protein levels. The expression and secretion of MMP- 3 were determined by using in situ hybridization, immunohistochemistry and western blot analysis. Results The results demonstrated a concentration - dependent increase in MMP - 3 mRNA and proteins expression, and showed that the expression was more significantly increased with IL- 6 treated by 10 and 100μ/ml than that treated without IL - 6. Conclusion IL - 6 upregulated MMP - 3 in HPDLC on both mRNA and protein levels, that suggest possibly important role for IL - 6 and MMP - 3 in the metabolism of ECM associated with periodontal tissue remodeling." @default.
- W2385485792 created "2016-06-24" @default.
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- W2385485792 date "2003-01-01" @default.
- W2385485792 modified "2023-10-17" @default.
- W2385485792 title "Effect of IL-6 on the expression of MMP-3 in human periodontal ligament cells" @default.
- W2385485792 hasPublicationYear "2003" @default.
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