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- W2385486561 abstract "Objective To study the expression of TBX3 gene in different molecular subtypes of breast cancer. Methods The expression of TBX3 in breast cancer,benign breast tumor and adjacent normal tissues were detected by immunohistochemistry. Results The expression of TBX3 in breast cancer was significantly higher than that of benign breast tumor and negative tumor edge tissue( Positive rates were 75. 49% 、45. 55%,30. 00%,respectively,P 0. 05); The expression of TBX3 in advanced breast cancer was significantly higher than that of early breast cancer( Positive rates in Phase Ⅰ、Ⅱ、Ⅲ breast cancer were64. 44% 、90. 32% 、85. 00%,respectively,P 0. 05); The expression of TBX3 in ER-positive breast cancer patients was higher than that of ER-negative patients( Positive rates were 82. 86% 、59. 38%,P 0. 05); The expression of TBX3 in KI-67 over expression breast cancer patients was higher than that of Ki-67 low expression breast cancer patients( Positive rates were 86. 79% 、63. 27%,P 0. 05); The expression of TBX3 in Basal-like subtype was the lowest in 4 kinds of molecular subtypes breast cancer patients( 36. 36%). The expression of TBX3 in luminal A、luminal B、Her-2 positive subtypes were 82. 50% 、81. 82% and72. 22%. Conclusion TBX3 may be one of the target genes of breast cancer,and it can be used as one of the malignant biomarkers of luminal subtype breast cancer." @default.
- W2385486561 created "2016-06-24" @default.
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- W2385486561 date "2014-01-01" @default.
- W2385486561 modified "2023-09-26" @default.
- W2385486561 title "The Expression and Clinical Significance of TBX3 Gene in Different Molecular Subtypes of Breast Cancer" @default.
- W2385486561 hasPublicationYear "2014" @default.
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