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- W2385494029 abstract "Objective: To explore the effects of aspirin on healing of gastric ulcer and pathogenesy.Methods: The gastric ulcers were induced with acetic acid in rats and then the rats with the gastric ulcer were randomly divided into model con-trol group,saline control group and aspirin group.The ulcerative appearance,ulcerative area and the number of inflamma-tory cells in granulation tissue were detected through histological method.The expressions of nuclear factor-κB,tumor necrosis factor-α and interleukin-8 in gastric mucosa were detected through immunohistochemical method.Results: The ulcerative area in aspirin group was increased compared with that of model or saline control group(P0.05).The number of inflammatory cells,the integral light density of nuclear factor-κB,tumor necrosis factor-α and interleukin-8 in aspirin group were increased compared with those of model or saline control group(P0.01).Conclusion: Aspirin up-regulate the expression of tumor necrosis factor-α and interleukin-8 by increasing the expressions of nuclear factor-κB and then aggra-vate inflammatory reaction,which inhibit the ulcer healing." @default.
- W2385494029 created "2016-06-24" @default.
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- W2385494029 date "2011-01-01" @default.
- W2385494029 modified "2023-09-26" @default.
- W2385494029 title "Aspirin up-regulate expressions of inflammatory factor by nuclear factor-κB to inhibit ulcer healing" @default.
- W2385494029 hasPublicationYear "2011" @default.
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