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- W2385497292 abstract "Objective To investigate the effects of hypertonic saline(HTS) on TNF-α and IL-10 mRNA expression in pancreatic tissue of rats after severe acute pancreatitis(SAP).Methods SAP was induced in rats by intraperitoneal injection of 20% L-arginine twice at an interval of 1 h.Then the rats were randomized into 4 groups: 1) control group;2) SAP without resuscitation(group A);3) SAP plus intravenous resuscitation with normal saline(group B);4) SAP plus intravenous resuscitation with HTS(7.5% sodium chloride 2 ml/kg) at 0,12,24 and 36 h(group C).The samples of pancreatic tissue were collected at the 24th and 48th h after induction.The expression of TNF-α and IL-10 mRNA in pancreas was detected by semi-quantitative RT-PCR.Pathological examination of the pancreas was also performed.Results As compared with those of resuscitation with NS,the expression of TNF-α mRNA of the animals receiving HTS significantly decreased(P0.05),and the expression of IL-10 mRNA increased more significantly after the induction of SAP(P0.01).Meanwhile,pancreatic histological score was reduced in animals treated with HTS(P0.01).Conclusions HTS resuscitation is an effective method to restore the balance of pro-and counter-inflammatory cytokines." @default.
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- W2385497292 date "2005-01-01" @default.
- W2385497292 modified "2023-09-27" @default.
- W2385497292 title "Effects of hypertonic saline on TNF-α and IL-10 mRNA expression in pancreatic tissue of rats after severe acute pancreatitis" @default.
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