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- W2385509486 abstract "Background and purpose:The acetylation level in nucleosomal histones,which is controlled by interactions between histone acetyl transferases and histone deacetylases(HDACs),is closely involved in regulation of gene expression.The abnormal function of HDACs is related to development of neoplasms.Histone deacetylase inhibitors(HDACIs)have antitumor effects through inhibiting HDACs.The purpose of this paper is to investigate the antitumor effect of MS-275,a histone deacetylase inhibitor,on human bladder cancer T24 cell,and provide a valuable research basis for clinical application.Methods:Cultured T24 cells were exposed to different concentrations of MS-275 for different durations.The cell growth inhibition was evaluated by MTT assay.The effect on proliferating ability of T24 cell was determined by clonogenic assay on plate.The cell apoptosis was qualitatively detected by optical microscope,electronic microscope and AnnexinV,PI-labeled flow cytometry, respectively.Results:The MTT assay revealed that MS-275 inhibited the growth of T24 cell lines not only in a concentration-dependent but also in a time-dependent manner,the growth inhibition ratio was(9.34±3.57)% when treated with 0.5μmol/L MS-275 for 72h,and(94.84±1.33)% with 8μmol/L for 120 h.The cloning efficiency was decreased from(55.67±6.51)% in negative control group to(2.33±0.58)% at concentration of 4μmol/L.Typical morphological change of apoptotic cells were observed by microscope.The apoptotic percentage at concentration of 1μmol/L、2μmol/L and 4μmol/L were 24.19%、30.77%and 38.51% quantitativel measured by which were significantly higher than that of negative control group(2.49%).Conclusions:MS-275 can inhibit bladder cancer in vitro through inducing apoptosis and mitotic death of cells.The results of this study suggest that histone deacetylase inhibitors are hopeful to become new effective drugs to treat bladder neoplasms." @default.
- W2385509486 created "2016-06-24" @default.
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- W2385509486 date "2006-01-01" @default.
- W2385509486 modified "2023-09-26" @default.
- W2385509486 title "Experimental study in vitro on histone deacetylase inhibitor MS-275 inhibiting bladder cancer" @default.
- W2385509486 hasPublicationYear "2006" @default.
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