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- W2385531279 abstract "Hepatitis C virus (HCV) infection is an important public health problem all over the world.Generally,HCV infection can cause acute self limited infections in a few infected patients,but more frequently,can cause chronic liver cell injury in other 70%～85% infected persons which maybe develop into cirrhosis and hepatocellular carcinoma in a high proportion.The mechanisms responsible for persistence or viral clearance are still unknown. But recent studies suggest that a vigorous multispecific cellular immune responses, particular those mediated by CD8 + cytotoxicity T lymphocytes (CTLs), are thought to play a pivotal role in the control of infection.To develop a useful therapeutic HCV vaccine for treatment of chronic HCV infection seems feasible.Indeed, induction of high titer,long lasting, and cross reactive neutralizing antibodies and a broad,stronger,multispecific cellular immune response that includes both helper T cells and CTLs may be necessary for an effective HCV vaccine.The final vaccine product may require multiple components that target various aspects of protective immunity.Finally, sterilizing immunity may not be necessary if a vaccine can be developed to prevent or therapy chronic infection of HCV,which is the major cause of morbidity and mortality from this disease.In this article,the advances of studies on HCV vaccine, especially the research situation of therapeutic vaccine,were discussed in details. Problems existing in the present and research strategies used in the future were also analyzed. [" @default.
- W2385531279 created "2016-06-24" @default.
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- W2385531279 date "2002-01-01" @default.
- W2385531279 modified "2023-09-23" @default.
- W2385531279 title "Recent advances in studies on therapeutic hepatitis C virus vaccine" @default.
- W2385531279 hasPublicationYear "2002" @default.
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