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- W2385535146 abstract "Objective To observe the effect of valsartan on the degradation system of extracellular matrix in glomerulosclerosis cell in rats.Methods Thirty male SD rats were randomly divided into group A,B and C.Group B and C received uninephrectomy and were injected Adriamycin through the tail vein one week later for the establishment of glomerulosclerosis model.Group A was injected normal saline via tail vein.Group C received lavage with valsartan 20 mg/kg once in the morning.Group A and B received lavage with water(2 mL) once in the morning.The 24-hour urine protein excretion,serum biochemisty indexes and the renal pathological changes were observed.The expressions of collagen Ⅳ and plasminogen activator inhibitor-1 were detected with immunohistochemistry method.The expression of plasminogen activator inhibitor-1 mRNA was detected with in situ hybridizatiion method.Results The 24-hour urine protein excretion was lower in 6 weeks(P0.05) and the serum albumin was significantly higher in 12 weeks(P0.05) in group C than that in group B.Most glomeruli in group B showed segmental glomerulosclerosis,and the glomerulosclerosis index was lower in group C than that in group B(P0.01).The expressions of collagen Ⅳ and plasminogen activator inhibitor-1 in group C were significantly lower than those in group B(P0.05).The expression of plasminogen activator inhibitor-1 mRNA was significantly higher in group C and very lower in group A(P0.05).The expression of collagen Ⅳ protein was positively correlated to plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1 mRNA.Conclusion Valsartan may relieve the degradation of extracellular matrix to slow the progress of glomerulosclerosis by lowering the expression of plasminogen activator inhibitor-1 in kidney." @default.
- W2385535146 created "2016-06-24" @default.
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- W2385535146 date "2010-01-01" @default.
- W2385535146 modified "2023-09-28" @default.
- W2385535146 title "Valsantan on the expression of plasminogen activator inhibitor-1 in rats with glomerulosclerosis" @default.
- W2385535146 hasPublicationYear "2010" @default.
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