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- W2385553262 abstract "Objective To observe expression of nuclear factor-κB(NF-κB) in myocardial cells and the change of heart function of rats with septic shock.Methods Twenty rats were randomly divided into two groups,10 rats in each group.The rats of experimental group were induced to the septic shock by cecal ligation and puncture(CLP),while the rats of control group were dealt with in the same way except that they were not subjected to CLP.NF-κB protein levels in myocardial cells and cardiac function were measured at 12 hours after CLP.Results Compared with the control group,NF-κB protein levels in myocardial cell were significantly elevated(P0.01 ).Meanwhile,maximal velocity increase/decrease of left ventricular pressure per second,left ventricular end diastolic pressure,heart rate,systolic arterial pressure and diastolic arterial pressure were decreased significantly,while left ventricular systolic pressure was increased markedly(P0.01).Conclusion The expression of NF-κB protein in myocardial cells were elevated during the process of septic shock induced by CLP,which might play an important role in the cardiac hypofunction." @default.
- W2385553262 created "2016-06-24" @default.
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- W2385553262 date "2010-01-01" @default.
- W2385553262 modified "2023-09-25" @default.
- W2385553262 title "Expression of nuclear factor-kappa B in myocardial cells and the change of heart function of rats with septic shock" @default.
- W2385553262 hasPublicationYear "2010" @default.
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