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- W2385568978 abstract "Objective To study the changes of coagulation function and its clinical significance in newborn infants with systemic inflammatory response syndrome (SIRS).Methods A total of 126 newborn infants diagnosed as SIRS were scored within the 24 hours after the admission according to the criteria of the critical-score-system for neonatal acute severity.In the meantime,their prothrombin time (PT),thrombin time (TT),activated partial thromboplastic time (APTT) and the D-Dimer (DD) levels and platelet counts (PLT) were determined.The patients were divided into the group A(having 2 SIRS entry critria items),group B (having 3 items) and group C (having 4 items) according to the 4 items of clinical criteria for diagnosis of SIRS. These patients were also divided into critical group and non-critical group according to the critical-score-system for neonatal acute severity,or survival group and nonsurvival group according to the prognosis.Their coagulation function were compared.Results The percentage of critical cases and mortality rate in SIRS newborns increased with increasing items of criteria for diagnosis of SIRS,so did the PT,TT,APTT and DD levels.The PT,TT,APTT and DD levels remarkably correlated with the items.There was no difference in the PT,TT,APTT between the survival group and nonsurvival group (P0.05),while plasma levels of DD in nonsurvival group was significantly higher than that in survival group (P0.01).The PT,TT, APTT and DD levels in critical group was higher than that in non-critical group (P0.01).Conclusion There was an activation of the coagulation system in the newborn infants with SIRS.The more items of the diagnostic criteria for SIRS,the patients had the more severe and much remarkable the coagulation disturbance and much higher the mortality." @default.
- W2385568978 created "2016-06-24" @default.
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- W2385568978 date "2004-01-01" @default.
- W2385568978 modified "2023-09-23" @default.
- W2385568978 title "Study of coagulation function in newborn infants with systemic inflammatory response syndrome." @default.
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