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- W2385574927 abstract "Objective: To observe the effect of Jiajian Sini San (JJSNS) on glucocorticoid receptor (GCR) in thymocyte of chronic psychological stressed rats. Methods: Rats were divided randomly into 4 groups, the control group (C), the model group (M), the JJSNS treated group (C 1) and the ginsenoside treated group (C 2). Weight of thymus gland was weighed by electro balance. Number of GCR in thymocyte was detected with radioimmunoassay (RIA) and its nuclear translocation rate (GCR NTR) was calculated. Results: Compared with Group C, the thymus weight index in Group M was lowered significantly (P0 05), and GCR in thymocyte showed a tendency to rise with the GCR NTR elevation significantly (P0 01). Compared with Group M, the thymus weight index was higher and GCR NRT was lower in Group C 1 and C 2 (P0 05 or P0 01), and JJSNS showed more effective in reducing GCR NTR than ginsenoside. The above mentioned parameters in Group C 1 were different from those in Group C insignificantly. Conclusion: JJSNS could weaken the inhibitory effect of glucocorticoid on thymus by means of suppressing the translocation activity of GCR from cytoplasm to nucleus in chronic psychological stressed rat." @default.
- W2385574927 created "2016-06-24" @default.
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- W2385574927 date "2002-01-01" @default.
- W2385574927 modified "2023-09-23" @default.
- W2385574927 title "Study on Effect of Jiajian Sini San on Glucocorticoid Receptor in Thymocyte of Chronic Psychological Stressed Rats" @default.
- W2385574927 hasPublicationYear "2002" @default.
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