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- W2385589264 abstract "Since no specific immune system exists in invertebrates,the innate immune system functions as the unique mechanism for invertebrates to resist pathogenic microorganism.The innate immune system of invertebrates is composed of cellular and humoral defence mechanisms that are triggered by pattern recognition receptor(PRR) molecules which evolve to recognize conserved products of microbial metabolism produced by microbial pathogens.Upon specific binding to features on the surface of microorganisms,these PRRs can either directly mediate microbial killing through encapsulation and phagocytosis or indirectly trigger a variety of defence reactions through activating serine protease cascades and intracellular immune signallingpathways which regulate the transcription of effector genes such as antimicrobial peptides.GNBPs and PGRPs are important PRRs in innate immune system for invertebrates.This paper will mainly focus on recent reserch development in invertebrates and function mechanisms of innate immune response of GNBPs and PGRPs." @default.
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- W2385589264 date "2010-01-01" @default.
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- W2385589264 title "Function of gram-negtive binding proteins and peptidoglycan-recognition proteins in invertebrate innate immune response." @default.
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