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- W2385605204 abstract "Objective To discuss the action of NF-κB in regulating TNF-α and to observe the change of NF-κB in four degree pancreatitis. Methods 63 SD rats were invided into four groups: the normal、necrotic and PTCD-intervention groups.Six,twelve and twenty four hours after the inducing of model HE,pancreatic histollgic score、immunohistochemistric and radio-immunity technique were adopted to detect the pathological changes, NF-κB and TNF-α.Result The pathological scores indicatded that the necrotic groups had a higher score than that in the other three groups characterized by hemorrhage and necrosis. In every stage necrotic groups had a higher level of NF-κB and TNF-α than that in the other groups(P0.05).PTCD acted as an inhibilor of NF-κB was able to hold back NF-κB effectly and alleviate the acute panereatitis. Conclusions NF-κB plays an importment role in inducing TNF-α, and it can affect the progress of acute pancreatitis. Restraining the NF-κB by PTCD can attenuates the rats pancreatitis." @default.
- W2385605204 created "2016-06-24" @default.
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- W2385605204 date "2005-01-01" @default.
- W2385605204 modified "2023-09-24" @default.
- W2385605204 title "The Role of NF-κB in the Pathogenesis of Rat Acute Pancreatitis Model" @default.
- W2385605204 hasPublicationYear "2005" @default.
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