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- W2385626727 abstract "OBJECTIVE:To investigate the expression of MiR-10 bin non-small-cell lung cancers and its correlation with clinical parameters.METHODS:Tumor specimens and adjacent normal tissues from 50 patients with NSCLC who underwent complete surgical resection were collected at First Affiliated Hospital of China Medical University from January1 st 2005to December 1st 2006.The expressions of miR-10 bin 50NSCLC tissues and adjacent normal tissues were examined using RT-PCR.Kaplan-Meier analysis was used to compare the differences in the survival of subgroups of patients.RESULTS:In the 50 NSCLC specimens and normal lung tissues examined,miR-10 bexpression was higher in 34 cases of NSCLC(2-delta delta CT normal=1.01±0.38,2-delta delta CT cancer=1.55±0.57,t=-2.182,P=0.034).Overexpression of miR-10 bwas correlated with advanced TNM stage(U=189,P= 0.010)and lymph node metastasis(χ2=6.65,P=0.010).No correlation was observed regarding gender,age,site of occurrence,histology or differentiation.The Kaplan-Meier analysis revealed that the 5-year survival rate was 4%(1/25)in patients with miR-10 boverexpression and32%(8/25)in patients with low miR-10 bexpression,which was statistically significant(P=0.011).CONCLUSIONS:The present study reported miR-10 bexpression pattern in NSCLC for the first time,suggesting miR-10 bplays an important role in NSCLC development." @default.
- W2385626727 created "2016-06-24" @default.
- W2385626727 creator A5085586746 @default.
- W2385626727 date "2014-01-01" @default.
- W2385626727 modified "2023-09-28" @default.
- W2385626727 title "Analysis of clinical and pathological significance of expression of miR-10b in the non-small cell lung cancer" @default.
- W2385626727 hasPublicationYear "2014" @default.
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