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- W2385628135 abstract "[Objective] To investigate the effect of ginkgo bilogo extract(GBE) on airway inflammation in rats with chronic obstructive pulmonary disease(COPD),as well as C-reactive protein(CRP) in serum and bronchoalveolar lavage fluid(BALF).[Methods] Forty Wistar rats were randomly divided into the following four groups,normal control group(group A),model group(group B),GBE early intervention group(group C),and GBE late intervention group(group D).In group B,C and D,COPD model was established through comprehensive factors of smoking,lipopolysaccharide using,and cold air stimulation.In group C and D,intraperitoneal injection of GBE was given during 1～14 d and 29～42 d in the treatment,respectively.43 days later,pathological changes in lung tissues,as well as CRP in serum and BALF were detected in all groups.[Results] ①Specific changes of different degree of COPD occurred in group B,C and D.②Compared with group A,pathological scores of airway inflammation in group B significantly increased(P 0.05 or P 0.01).Compared with group B,pathological scores of airway inflammation in group C and D greatly reduced(P 0.05 or P 0.01),and those in group D were higher than those in group C(P 0.05).③Compared with group A,CRP in serum and BALF in group B greatly increased(P 0.01).Compared with group B,CRP in serum and BALF in group C significantly decreased(P 0.01),and reduced too in group D(P 0.05).[Conclusion] GBE can lower CRP expression in serum and BALF,and inhibit airway inflammatory reaction,indicating that GBE can control airway inflammation of COPD and systemic inflammatory reaction." @default.
- W2385628135 created "2016-06-24" @default.
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- W2385628135 date "2012-01-01" @default.
- W2385628135 modified "2023-09-22" @default.
- W2385628135 title "Effect of Ginkgo Biloba Extract on Inflammatory Reaction in Rats With Chronic Obstructive Pulmonary Disease" @default.
- W2385628135 hasPublicationYear "2012" @default.
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