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- W2385650958 abstract "Objective To investigate the antiarrhythmic effects of pilocarpine in rats.Methods Aconitine and BaCl2 were used to make experimental arrhythmic models in Wistar rats.The effects of pilocarpine(0.2 mg·kg-1,iv) on the occurrence of arrhythmias was observed.Results Pilocarpine substantially depressed the occurrence of arrhythmias induced by aconitine and BaCl2.The occurrence of arrhythmias were delayed obviously(P0.05) after given pilocarpine and the survival time after the occurrence of arrhythmias were prolonged obviously also(P0.05) in aconitine model.The occurrence of arrhythmias were delayed obviously(P0.01) and the persistence of arrhythmias were decreased obviously also(P0.01) in BaCl2 model.4-DAMP(antagonist of M3 receptors) could reverse the effects of pilocarpine completely.Conclusion Pilocarpine plays the antiarrhythmic roles by activating cardiac M3 receptors of Wistar rats on the arrhythmias induced by aconitine and BaCl2." @default.
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- W2385650958 date "2012-01-01" @default.
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- W2385650958 title "Effect of pilocapin on arrhythmia in rats" @default.
- W2385650958 hasPublicationYear "2012" @default.
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