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- W2385655357 abstract "Objective:To investigate the pathophysiologic changes of systemic inflammatory response syndrome(SIRS) and acute high altitude reaction syndrome(AHARS) as well as relationship between each other.Methods: Clinical cases and animal models were respectively randomly divided into three groups: high altitude group,moderate high altitude group and flat land group.SIRS/ARDS models were established by making lung lymph fistula in sheep,by cecum ligation and puncture in rabbits and KM mice,and by severe TBSA burn in SD rats.A clinical multicenter research was completed by using the same criteria in 540 MODS patients.Three MODS diagnostic criteria were used and the accuracy of prognosis was tested comparatively.Results: ① In animal model groups,there were significant difference in many parameters such as PAP,PAWP,QL,PS,PC,TXB2,PGFia,ET-1,CGRP,L-ENK and HSP70 in three different altitudinal groups.②Analysis of area under ROC curve,sensitivity,specificity and 95% confidence interval indicated that the diagnostic criteria in high altitude was superior to that in flat land(P0.05).Conclusion: There is probably common pathophysiologic basis in both AHARS and SIRS/ARDS/MODS induced by plateau hypoxia or other exogenous insults factors.A united diagnostic scoring system should be established and it may be helpful for increasing early-stage diagnosis rate and decreasing mortality rate." @default.
- W2385655357 created "2016-06-24" @default.
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- W2385655357 date "2007-01-01" @default.
- W2385655357 modified "2023-09-24" @default.
- W2385655357 title "Preliminary research of united diagnostic scoring system in systemic inflammatory response syndrome and acute high altitude reaction syndrome" @default.
- W2385655357 hasPublicationYear "2007" @default.
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