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- W2385655693 abstract "Objective To investigate the effects of HA14-1 on leukemic cells and the relationship between the effects and the level of Bcl-2、BclxL and Bax in these cells.Methods The leukemic cell lines of U937、BALL-1 and Jurkat clone E6-1 were co-cultured with different concentrations of HA14-1(25,50,75,100 μmol/L) for 4 hours.The mean fluorescent index(MFI) and the apoptosis of Bcl-2、Bax 、Bcl-xL were detected with the FCM before and after the treatment of HA14-1.Results ①With the increase of concentration of HA14-1,the viability of the cells were decreased from(93.7±1.5)% to(14.8±1.9)% in U937 cell;from(94.7±1.5)% to(12.4±1.3)% in Jurkat clone E6-1;from(94.7±0.8)% to(0.9±0.6)% in BALL-1.With the same HA14-1 concentration,the viability of different cells lines were negatively related with the Bcl-2 level.②With the increase of HA14-1 concentration,apoptosis rate increased gradually,such as from(0.5±1.0)% to(60.1±2.6)% in Jurkat clone E6-1.With the high concentration(100 μmol/L) of HA14-1,extreme necrosis was observed.The cell necrotic rate increased from less than(3.3±0.6)% to(26.7±1.6)%.③With the treatment of HA14-1,the Bcl-2 was markedly decreased in all three cells,but the Bcl-xL and Bax were not changed significantly.Conclusion HA14-1 can induce apoptosis of leukemia cells with different Bcl-2 level,and the sensitivity of leukemia cells to HA14-1 is opposite to their Bcl-2 expression level,that is cell with high Bcl-2 level is more sensitive to HA14-1,which offers theoretical basis for reversing MDR clinically." @default.
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- W2385655693 date "2006-01-01" @default.
- W2385655693 modified "2023-09-24" @default.
- W2385655693 title "Effects of HA14-1 on Leukemia Cell Lines" @default.
- W2385655693 hasPublicationYear "2006" @default.
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