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- W2385657070 abstract "Objective To explore the effects of interleukin-15 (IL-15) on the apoptosis of T lymphocyte induced by X-ray.[WT5”HZ]Methods T lymphocytes isolated from bone marrow of 30 healthy volunteers were randomized to experimental group (IL-15 100 μg/L and X-ray irradiation) and control group (X-ray irradiation).The changes of T lymphocyte subgroups,bcl-XL,bax and bcl-2 protein and apoptosis of the lymphocytes were observed by using flow cytometry (FCM) and immunofluorescence after irradiation with X-ray.Results After irradiation with X-ray,a great deal of apoptosis of lymphocytes occurred.In the experimental group,the apoptotic rate was significantly decreased as compared with that in the control group (P 0.01).The expression rate of T lymphocyte subtypes in experimental group was higher than in the control group (P 0.01).The expression of bcl-2,bcl-XL gene was up-regulated,while that of bax gene was down-regulated in experimental group as compared with that in control group (P 0.01).Conclusion IL-15 could obviously inhibite the apoptosis of lymphocytes induced by X-ray irradiation and could reduce the injury of immunization caused by acute irradiation diseases.." @default.
- W2385657070 created "2016-06-24" @default.
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- W2385657070 date "2005-01-01" @default.
- W2385657070 modified "2023-09-28" @default.
- W2385657070 title "Protective effects of interleukin-15 on the apoptosis of T lymphocyte induced by X-ray" @default.
- W2385657070 hasPublicationYear "2005" @default.
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