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- W2385678244 abstract "Objective: To observe the preventive and therapeutic effects of antithrombin-Ⅲ(AT-Ⅲ) on experimental disseminated intravascular coagulation(DIC) in rabbits. Methods: Rabbits were at random divided into the control and AT-Ⅲ plus lipopolysaccharide(LPS) or AT-Ⅲ plus thromboplastin(Tp) groups. Experimental DIC was induced by injection of LPS or Tp. AT-Ⅲ was intravenously injected zfter the injection of LPS or Tp. 2. 5 hours later, blood sample were drawn and the concentration of fibrinogen, pro-thrombin time(PT), 3P test, platelet count, AST and CK was measured. Results: As compared with the controls, it was found that the platelet count and plasma concentration of fibrinogen were significantly decreased and the PT time showed no significant difference, but the positive degree of 3P test was remarkably decreased and the pathologic changes of the heart, liver, lung and kindney were slight in the high-dose AT-Ⅲ group. Conclusion: AT-Ⅲ can inhibit the DIC and inflammation response caused by LPS or Tp." @default.
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- W2385678244 date "2002-01-01" @default.
- W2385678244 modified "2023-09-23" @default.
- W2385678244 title "Observation of Preventive and Therapeutic Effects of Antithrombin-III on Experimental Disseminated Intravascular Coagulation" @default.
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