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- W2385684203 abstract "Objective The aim of this study is to evaluate the possible effects of Tamoxifen on chemosensitization of T-24 bladder carcinoma cell line.Meterials and methods In vitro,chemosensitivity tests were done with T-24 bladder carcinoma cell line and 4 cytotoxic agents (Adriamycin,ADM;Mitomycin C,MMC;Thiotepa,Thiot; Vincristine,VCR) in the presence or absence of graded concentration of Tamoxifen (5 μM,10 μM)。Growth inhibition tests were performed with Tetrazolium (MTT) assay.Through the curves of growth inhibition of T-24 treated with grade concentration of cytotoxic agents,the chemosensitization of Tamoxifen was observed.Results Tamoxifen at the concentration of 5 μM and 10 μM increased significantly the chemosensitivity of ADM by 1.95 to 7.06 fold and the chemosensitivity of VCR by 6.94 to 14.55 fold,respectively.The chemosensitivity of ADM and VCR could be significantly protentiated by Tamoxifen at the concentration of 5 μM and 10 μM ( P 0 05).But Tamoxifen at 5 μM and 10 μM could not increase the chemosensitivity of MMC and Thiot,significantly.Conclusions In vitro,Tamoxifen at the concentration of 5 μM and 10 μM can significantly enhance chemosensitivity of ADM and VCR to T-24 bladder cancer cell line.For less side effects of Tamoxifent at such concentration,it might be a safe,potential chemosensitizer in systemic treatment or intravesical instillation to human bladder cancers." @default.
- W2385684203 created "2016-06-24" @default.
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- W2385684203 date "2000-01-01" @default.
- W2385684203 modified "2023-09-24" @default.
- W2385684203 title "The Chemosensitization Effects of Tamoxifen of T-24 Bladder Carcinoma Cell Line" @default.
- W2385684203 hasPublicationYear "2000" @default.
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