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- W2385709076 abstract "Objective To observe the initial ultrastructure and expression of surfactant protein A(SPA)in the lung of passive smoking mice.Methods 48 healthy mice of 4-6 weeks old were choosed and dislocated to death at the 1st,2nd,3rd and 4th week after passive smoking.Lung samples were prepared for electron-microscopy in order to observe the morphological changes,and the expression of SPA in passive smoking mice were investigated using the immunohistochemical method and image analysis system.Results The ultrastructure of transmission electronic microscopy:mitochondrial of type Ⅱ alveolar cell was vacuolar,osmiophilic multilamellar body was increased and degranuled.Alveolar macrophage had massive phagogranules and angioendothelial cell nuclear chromatin was marginized to be nubby or pycnosis,nucleus perigap was increased.The level of SPA in experimental group was gradually decreased.There was significantly difference between experimental group and controlled group.Conclusion Ultra-structure changed in the lung of passive smoking mice,the expression of SPA was decreased in experimental group,which suggest that pulmonary surfactant function is reduced and bronchiolitis and chronic alveolar inflammation occured." @default.
- W2385709076 created "2016-06-24" @default.
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- W2385709076 date "2007-01-01" @default.
- W2385709076 modified "2023-09-25" @default.
- W2385709076 title "A study on the initial ultrastructure and expression of surfactant protein A in the lung of passive smoking mice" @default.
- W2385709076 hasPublicationYear "2007" @default.
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