Matches in SemOpenAlex for { <https://semopenalex.org/work/W2385709827> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2385709827 abstract "Aim To study the protective effects of gly-cosides cistanche(GCs) on model of Alzheimers dis-ease(AD) in mice induced by β-amyloid peptide(β-AP) and its mechanism.Methods AD animal model was established by a single intracerebroventricular injection of micromolar doses of β-AP_(25-35) in mice.After 10 days,a step-through type passive avoidance training was performed on the mice for one time,followed by a ability assessment of learning and memory;superoxidase dismutase(SOD) activities,gultathionine peroxides(GSH-Px) activities and malondialdehyde(MDA) contents in mice brain were also assessed;the pathological changes in the AD mice brain were observed by electronic microscopy;TUNEL method was used to observe the apoptosis of cells;the immunohistochemical SABC method was used to determine expression of Bcl-2 and Bax.Results GCs markedly enhanced the ability of learning and memory which induce by β-AP in AD mice and increased the activity of SOD and GSH-Px,and reduced MDA contents in mice brain;GCs also ameliorated some pathological features of AD mice brain and significantly decreased cell apoptosis in mice brain.A decrease in the Bax expression and a increase in the Bcl-2 expression were also observed.Conclusions GCs significantly improves the ability of learning and memory induced by β-AP in AD mice and its possible mechanism of action may involve: Enhancement of free radical scavengers;inhibition of lipid peroxidation;inhibition of β-AP precipitation and apoptosis in mice brain cells induced by β-AP." @default.
- W2385709827 created "2016-06-24" @default.
- W2385709827 creator A5009426777 @default.
- W2385709827 creator A5075010623 @default.
- W2385709827 date "2006-01-01" @default.
- W2385709827 modified "2023-09-23" @default.
- W2385709827 title "The effects of glycosides of cistanche on learning and memory in β-amyloid peptide induced Alzheimers disease in mice and its possible mechanism" @default.
- W2385709827 hasPublicationYear "2006" @default.
- W2385709827 type Work @default.
- W2385709827 sameAs 2385709827 @default.
- W2385709827 citedByCount "2" @default.
- W2385709827 countsByYear W23857098272014 @default.
- W2385709827 crossrefType "journal-article" @default.
- W2385709827 hasAuthorship W2385709827A5009426777 @default.
- W2385709827 hasAuthorship W2385709827A5075010623 @default.
- W2385709827 hasConcept C126322002 @default.
- W2385709827 hasConcept C134018914 @default.
- W2385709827 hasConcept C185592680 @default.
- W2385709827 hasConcept C190283241 @default.
- W2385709827 hasConcept C196795494 @default.
- W2385709827 hasConcept C2775838275 @default.
- W2385709827 hasConcept C2776151105 @default.
- W2385709827 hasConcept C2778401633 @default.
- W2385709827 hasConcept C2779134260 @default.
- W2385709827 hasConcept C2780829032 @default.
- W2385709827 hasConcept C502032728 @default.
- W2385709827 hasConcept C55493867 @default.
- W2385709827 hasConcept C71924100 @default.
- W2385709827 hasConcept C98274493 @default.
- W2385709827 hasConceptScore W2385709827C126322002 @default.
- W2385709827 hasConceptScore W2385709827C134018914 @default.
- W2385709827 hasConceptScore W2385709827C185592680 @default.
- W2385709827 hasConceptScore W2385709827C190283241 @default.
- W2385709827 hasConceptScore W2385709827C196795494 @default.
- W2385709827 hasConceptScore W2385709827C2775838275 @default.
- W2385709827 hasConceptScore W2385709827C2776151105 @default.
- W2385709827 hasConceptScore W2385709827C2778401633 @default.
- W2385709827 hasConceptScore W2385709827C2779134260 @default.
- W2385709827 hasConceptScore W2385709827C2780829032 @default.
- W2385709827 hasConceptScore W2385709827C502032728 @default.
- W2385709827 hasConceptScore W2385709827C55493867 @default.
- W2385709827 hasConceptScore W2385709827C71924100 @default.
- W2385709827 hasConceptScore W2385709827C98274493 @default.
- W2385709827 hasOpenAccess W2385709827 @default.
- W2385709827 hasRelatedWork W2024149978 @default.
- W2385709827 hasRelatedWork W2025128272 @default.
- W2385709827 hasRelatedWork W2171958520 @default.
- W2385709827 hasRelatedWork W2325897769 @default.
- W2385709827 hasRelatedWork W2365977559 @default.
- W2385709827 hasRelatedWork W2373590209 @default.
- W2385709827 hasRelatedWork W2376146648 @default.
- W2385709827 hasRelatedWork W2381758679 @default.
- W2385709827 hasRelatedWork W2386691617 @default.
- W2385709827 hasRelatedWork W2388380040 @default.
- W2385709827 hasRelatedWork W2392539842 @default.
- W2385709827 hasRelatedWork W2510456718 @default.
- W2385709827 hasRelatedWork W2528054127 @default.
- W2385709827 hasRelatedWork W2794046825 @default.
- W2385709827 hasRelatedWork W2883181679 @default.
- W2385709827 hasRelatedWork W3002242413 @default.
- W2385709827 hasRelatedWork W3005825283 @default.
- W2385709827 hasRelatedWork W3041993440 @default.
- W2385709827 hasRelatedWork W3145315636 @default.
- W2385709827 hasRelatedWork W35143237 @default.
- W2385709827 isParatext "false" @default.
- W2385709827 isRetracted "false" @default.
- W2385709827 magId "2385709827" @default.
- W2385709827 workType "article" @default.