Matches in SemOpenAlex for { <https://semopenalex.org/work/W2385714422> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2385714422 abstract "The purpose of this artical is to study the preparation and biodistribution in animal of dopamine transporter imaging agent ~(125)I- β-CIT. β-CIT was ~(125)I radioiodinated with odogen method, the dynamic distribution of ~(125)I-β-CIT in brain and critical organs were studied with SD rat (atuoradiography) and NIH mice respectively. The radiolabelling yield of ~(125)I-β-CIT was 84%, the radiochemical purity was better than 98%. Blood clearance could be explained by two-compartment model with a duration of 12h, (α = 3.87, T_(1/2α) =0.179, β =0.162, T_(1/2β) =4.276) and three-compartment model in 24h, (Pi= 5.28, T_(1/2Pi)= 0.131, α = 0.403, T_(1/2α). = 1.719, β= 0.040, T_(1/2β) = 17.298). The maxim uptake rate of brain (9.1% ± 1.0%) was reaches at lh, while at 24h, the target/noise ratio was higher. Critical organs liver, lung, spleen and kidney had high uptake rate [(9.881 1.43)- (16.29± 1.72)], except liver, other organs showed quick clearance (T_(1/2)4h). Thyroid had a low uptake. Autoradiography of the brain showed that striatum uptake was good, striatum /cerebral cortex radioactivity ratio achieved maximum at 20h. The results show that ~(125)-β-CIT has a high striatum uptake and good stability in vivo, can provide good SPECT forages, the best acquisition time of SPECT may be about 20h after i.v.." @default.
- W2385714422 created "2016-06-24" @default.
- W2385714422 creator A5053998832 @default.
- W2385714422 date "2000-01-01" @default.
- W2385714422 modified "2023-09-28" @default.
- W2385714422 title "~(125)I-β-CIT Biodistribution Study in animals" @default.
- W2385714422 hasPublicationYear "2000" @default.
- W2385714422 type Work @default.
- W2385714422 sameAs 2385714422 @default.
- W2385714422 citedByCount "0" @default.
- W2385714422 crossrefType "journal-article" @default.
- W2385714422 hasAuthorship W2385714422A5053998832 @default.
- W2385714422 hasConcept C111368507 @default.
- W2385714422 hasConcept C126322002 @default.
- W2385714422 hasConcept C127313418 @default.
- W2385714422 hasConcept C150903083 @default.
- W2385714422 hasConcept C177322064 @default.
- W2385714422 hasConcept C185592680 @default.
- W2385714422 hasConcept C202751555 @default.
- W2385714422 hasConcept C203635412 @default.
- W2385714422 hasConcept C207001950 @default.
- W2385714422 hasConcept C2777807558 @default.
- W2385714422 hasConcept C2780062018 @default.
- W2385714422 hasConcept C2780931953 @default.
- W2385714422 hasConcept C2781041448 @default.
- W2385714422 hasConcept C2989005 @default.
- W2385714422 hasConcept C513476851 @default.
- W2385714422 hasConcept C55493867 @default.
- W2385714422 hasConcept C71924100 @default.
- W2385714422 hasConcept C86803240 @default.
- W2385714422 hasConceptScore W2385714422C111368507 @default.
- W2385714422 hasConceptScore W2385714422C126322002 @default.
- W2385714422 hasConceptScore W2385714422C127313418 @default.
- W2385714422 hasConceptScore W2385714422C150903083 @default.
- W2385714422 hasConceptScore W2385714422C177322064 @default.
- W2385714422 hasConceptScore W2385714422C185592680 @default.
- W2385714422 hasConceptScore W2385714422C202751555 @default.
- W2385714422 hasConceptScore W2385714422C203635412 @default.
- W2385714422 hasConceptScore W2385714422C207001950 @default.
- W2385714422 hasConceptScore W2385714422C2777807558 @default.
- W2385714422 hasConceptScore W2385714422C2780062018 @default.
- W2385714422 hasConceptScore W2385714422C2780931953 @default.
- W2385714422 hasConceptScore W2385714422C2781041448 @default.
- W2385714422 hasConceptScore W2385714422C2989005 @default.
- W2385714422 hasConceptScore W2385714422C513476851 @default.
- W2385714422 hasConceptScore W2385714422C55493867 @default.
- W2385714422 hasConceptScore W2385714422C71924100 @default.
- W2385714422 hasConceptScore W2385714422C86803240 @default.
- W2385714422 hasLocation W23857144221 @default.
- W2385714422 hasOpenAccess W2385714422 @default.
- W2385714422 hasPrimaryLocation W23857144221 @default.
- W2385714422 hasRelatedWork W1020195997 @default.
- W2385714422 hasRelatedWork W1957807342 @default.
- W2385714422 hasRelatedWork W1998447908 @default.
- W2385714422 hasRelatedWork W2018741537 @default.
- W2385714422 hasRelatedWork W2107294913 @default.
- W2385714422 hasRelatedWork W2350073901 @default.
- W2385714422 hasRelatedWork W2355464939 @default.
- W2385714422 hasRelatedWork W2358660776 @default.
- W2385714422 hasRelatedWork W2360028957 @default.
- W2385714422 hasRelatedWork W2362918399 @default.
- W2385714422 hasRelatedWork W2362947049 @default.
- W2385714422 hasRelatedWork W2364307152 @default.
- W2385714422 hasRelatedWork W2364948372 @default.
- W2385714422 hasRelatedWork W2366196023 @default.
- W2385714422 hasRelatedWork W2372777114 @default.
- W2385714422 hasRelatedWork W2374923925 @default.
- W2385714422 hasRelatedWork W2383180759 @default.
- W2385714422 hasRelatedWork W2393702721 @default.
- W2385714422 hasRelatedWork W3028813572 @default.
- W2385714422 hasRelatedWork W177022105 @default.
- W2385714422 isParatext "false" @default.
- W2385714422 isRetracted "false" @default.
- W2385714422 magId "2385714422" @default.
- W2385714422 workType "article" @default.